VU6010608 is a negative allosteric modulator of the metabotropic glutamate receptor 7 (mGlu7), with an IC50 value of 0.76 μM, and effectively crosses the blood-brain barrier. This compound has been shown to inhibit long-term potentiation (LTP) of Schaffer-collateral CA1 synapses in mouse brain slices induced by high-frequency stimulation. VU6010608 is suitable for research applications investigating neurological disorders and the modulation of synaptic plasticity.
VU6010608 is a negative allosteric modulator of the metabotropic glutamate receptor 7 (mGlu7), with an IC50 value of 0.76 μM, and effectively crosses the blood-brain barrier. This compound has been shown to inhibit long-term potentiation (LTP) of Schaffer-collateral CA1 synapses in mouse brain slices induced by high-frequency stimulation. VU6010608 is suitable for research applications investigating neurological disorders and the modulation of synaptic plasticity.
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