Fig. 1 · Structure
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VU6012962
mGlu7 NAM
VU6012962 is a negative allosteric modulator of the metabotropic glutamate receptor 7 (mGlu7 NAM) with an IC50 of 347 nM. This compound demonstrates oral bioavailability and the ability to penetrate the central nervous system (CNS). VU6012962 is primarily utilized in research focused on neurological disorders and synaptic transmission modulation, providing insights into mGlu7 receptor functions and therapeutic potentials.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2313526-86-0 |
| Applications | mGlu7 NAM |
| Formula | C21H19F3N4O4 |
| Molecular Weight | 448.40 |
| SMILES | O=C(C1=CC=C(OCC2CC2)C(OC)=C1)NC3=C(N4C=NC=N4)C=CC(OC(F)(F)F)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.