VU6031545 is a potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu 5), exhibiting an IC50 of 15 nM. This compound demonstrates significant brain penetrance and oral bioavailability in rat models, making it valuable for exploring the role of mGlu 5 in neurological disorders. Research applications include the investigation of anxiety, depression, and other neuropsychiatric conditions.
VU6031545 is a potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu 5), exhibiting an IC50 of 15 nM. This compound demonstrates significant brain penetrance and oral bioavailability in rat models, making it valuable for exploring the role of mGlu 5 in neurological disorders. Research applications include the investigation of anxiety, depression, and other neuropsychiatric conditions.
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