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VU6031545

mGlu 5 Negative Allosteric Modulator

VU6031545 is a potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu 5), exhibiting an IC50 of 15 nM. This compound demonstrates significant brain penetrance and oral bioavailability in rat models, making it valuable for exploring the role of mGlu 5 in neurological disorders. Research applications include the investigation of anxiety, depression, and other neuropsychiatric conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	3107596-27-7
Applications	mGlu 5 Negative Allosteric Modulator
Formula	C₁₆H₁₅N₃O₃S₂
Molecular Weight	361.44
SMILES	O=C(NC1=NC(C)=CS1)C2=NC3=C(SC=C3)C(O[C@@H]4CCOC4)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.