Fig. 1 · Structure
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VU6043653
mGlu5 Negative Allosteric Modulator
VU6043653 is a potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu5), exhibiting an IC50 value of 325 nM for human mGlu5. This compound selectively influences mGlu5 signaling pathways, making it a valuable tool for studying neuropharmacology and neurodegenerative diseases. Its ability to cross the blood-brain barrier enhances its utility in in vivo research applications focused on central nervous system disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 3032791-06-0 |
| Applications | mGlu5 Negative Allosteric Modulator |
| Formula | C16H14FN5O2 |
| Molecular Weight | 327.31 |
| SMILES | CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN(C)N=C3)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.