Fig. 1 · Structure
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VUF 10214
H4 Receptor Ligand
VUF 10214 is a selective H4 receptor ligand with a pKi value of 8.25. This compound demonstrates notable anti-inflammatory activity in a carrageenan-induced paw edema model in rats, making it a valuable tool for research on inflammatory diseases. Its mechanism of action and high affinity for the H4 receptor position it as an important reagent in studying the role of this receptor in various inflammatory processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 848837-33-2 |
| Applications | H4 Receptor Ligand |
| Formula | C13H14Cl2N4O |
| Molecular Weight | 313.18 |
| SMILES | O=C1NC2=C(N=C1N3CCN(CC3)C)C=C(C(Cl)=C2)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.