Fig. 1 · Structure
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VUF14480
hH4 Receptor Agonist
VUF14480 is a partial agonist of the histamine H4 (hH4) receptor, primarily mediating G protein signaling and β-arrestin2 recruitment. This compound demonstrates covalent binding to the hH4 receptor, with a pKi of 6.3 for the wild-type receptor. VUF14480 partially activates hH4 receptor signaling pathways, making it a valuable tool in the study of inflammatory diseases and related biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 1605304-31-1 |
| Applications | hH4 Receptor Agonist |
| Formula | C17H20N4 |
| Molecular Weight | 280.38 |
| SMILES | N=1C(=NC(=CC1C=2C=CC=CC2)N3CCN(C)CC3)C=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.