Fig. 1 · Structure
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Vupanorsen sodium
ANGPTL Inhibitor
Vupanorsen sodium is an N-acetyl galactosamine-conjugated antisense oligonucleotide that specifically inhibits the synthesis of Angiopoietin-like 3 (ANGPTL3) protein. This compound is effective in lowering triglyceride levels and reducing atherogenic lipoproteins, making it a valuable tool for research in lipid metabolism and cardiovascular disease. Its potential applications extend to studies aimed at understanding the role of ANGPTL3 in dyslipidemia and associated disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2172852-12-7 |
| Applications | ANGPTL Inhibitor |
| Formula | C296H414N86Na20O15P20S13 |
| Molecular Weight | 8665.5 (free acid) |
| Synonyms | IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.