Fig. 1 · Structure
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VVD-699
RAS-p110α Blocker
VVD-699 is a covalent inhibitor targeting the RAS-p110α interaction, demonstrating oral bioavailability. It effectively inhibits the activation of PI3Kα with an IC50 of 104 nM in H358 cells and reduces phosphorylated AKT levels. This compound is relevant for research into KRAS mutant and amplified cancers, providing insights into potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3055319-82-6 |
| Applications | RAS-p110α Blocker |
| Formula | C25H30ClFN2O6S2 |
| Molecular Weight | 573.10 |
| SMILES | COC1=CC(C2=C(Cl)C=CC=C2)=C(S(N3CC[C@](C(N[C@@H](/C=C\S(C)(=O)=O)C)=O)(F)C[C@H]3C)(=O)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.