Fig. 1 · Structure
Documents & Downloads
VX-984
DNA-PK Inhibitor
VX-984 is a potent and selective DNA-PK inhibitor that effectively penetrates the blood-brain barrier. It disrupts the non-homologous end joining (NHEJ) repair pathway, leading to an increase in DNA double-strand breaks (DSBs). This compound has significant research applications in the study of glioblastomas (GBM) and non-small cell lung cancer (NSCLC). Ideal for investigations into cancer therapy and DNA damage response mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1476074-39-1 |
| Applications | DNA-PK Inhibitor |
| Formula | C23H21D2N7O |
| Molecular Weight | 415.49 |
| Synonyms | M9831 |
| SMILES | O=C(C1=CC=NC2=C([C@H](C)CNC3=CC(C4=C([2H])N=C(C)N=C4[2H])=NC=N3)C=CC=C12)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.