Fig. 1 · Structure
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VY-3-135
ACSS2 Inhibitor
VY-3-135 is a potent, orally active inhibitor of ACSS2, demonstrating an IC50 value of 44 nM. This compound exhibits high specificity for ACSS2 over other members of the AcCoA synthetase family, notably not inhibiting ACSS1 or ACSS3. VY-3-135 is valuable for research applications focused on breast cancer, providing insights into metabolic pathways and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1824637-41-3 |
| Applications | ACSS2 Inhibitor |
| Formula | C26H27N3O3 |
| Molecular Weight | 429.51 |
| SMILES | CCN(C(C(C1=CC=CC=C1)(C2=CC=CC=C2)O)=N3)C4=C3C=CC(C(NC[C@@H](C)O)=O)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.