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Waglerin-1

Catalog No.: A66702
nAChR antagonist
Waglerin-1 is a 22-amino acid peptide that acts as a competitive antagonist of the muscle nicotinic acetylcholine receptor (nAChR). It effectively inhibits nAChR-mediated signaling, making it a valuable tool for studying neuromuscular transmission and muscle physiology. This peptide is utilized in various research applications, including the investigation of synaptic mechanisms and the development of therapeutic strategies for neuromuscular disorders.
Waglerin-1 145038-84-2 nAChR antagonist
Grouped product items
Size Price Stock Qty
1mg
$50.00
In stock
5mg
$125.00
In stock
10mg
$200.00
In stock
25mg
$405.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionWaglerin-1 is a 22-amino acid peptide that acts as a competitive antagonist of the muscle nicotinic acetylcholine receptor (nAChR). It effectively inhibits nAChR-mediated signaling, making it a valuable tool for studying neuromuscular transmission and muscle physiology. This peptide is utilized in various research applications, including the investigation of synaptic mechanisms and the development of therapeutic strategies for neuromuscular disorders.
Product Information
Catalog NumA66702
FormulaC112H175N37O26S2
Molecular Weight2519.95
CAS Number145038-84-2
SequenceGly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys-His-Pro-Pro-Cys-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg (Disulfide bridge: Cys9-Cys13)
Sequence shorteningGGKPDLRPCHPPCHYIPRPKPR (Disulfide bridge: Cys9-Cys13)
SMILESO=C1C2(N(C(=O)[C@H](CC3=CN=CN3)NC(=O)[C@@H](NC(=O)[C@H]4N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(CNC(CN)=O)=O)CCCCN)=O)CCC5)CC(O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC4)CSSC[C@@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC7=CC=C(O)C=C7)C(N[C@H](C(=O)N8[C@H](C(N[C@H](C(=O)N9[C@H](C(N[C@H](C(=O)N%10[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CCC%10)CCCCN)=O)CCC9)CCCNC(=N)N)=O)CCC8)[C@H](CC)C)=O)=O)=O)NC(=O)[C@]%11(N1CCC%11)[H])CCC2)[H]
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Neuronal Signaling > nAChR