Fig. 1 · Structure
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Waglerin-1
nAChR antagonist
Waglerin-1 is a 22-amino acid peptide that acts as a competitive antagonist of the muscle nicotinic acetylcholine receptor (nAChR). It effectively inhibits nAChR-mediated signaling, making it a valuable tool for studying neuromuscular transmission and muscle physiology. This peptide is utilized in various research applications, including the investigation of synaptic mechanisms and the development of therapeutic strategies for neuromuscular disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 145038-84-2 |
| Applications | nAChR antagonist |
| Formula | C112H175N37O26S2 |
| Molecular Weight | 2519.95 |
| SMILES | O=C1C2(N(C(=O)[C@H](CC3=CN=CN3)NC(=O)[C@@H](NC(=O)[C@H]4N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(CNC(CN)=O)=O)CCCCN)=O)CCC5)CC(O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC4)CSSC[C@@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC7=CC=C(O)C=C7)C(N[C@H](C(=O)N8[C@H](C(N[C@H](C(=O)N9[C@H](C(N[C@H](C(=O)N%10[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CCC%10)CCCCN)=O)CCC9)CCCNC(=N)N)=O)CCC8)[C@H](CC)C)=O)=O)=O)NC(=O)[C@]%11(N1CCC%11)[H])CCC2)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.