WAY-100289 is a selective antagonist of the 5-HT3 receptor, demonstrating high affinity with a pA2 value of 8.9 in isolated rat vagus nerve studies. This compound effectively inhibits the Bezold-Jarisch reflex in both anesthetized and awake rat models, highlighting its potential applications in neuropharmacological research and studies of gastrointestinal function. Its oral bioavailability makes it a valuable tool for investigating the therapeutic roles of 5-HT3 receptor modulation in various physiological and pathological states.
WAY-100289 is a selective antagonist of the 5-HT3 receptor, demonstrating high affinity with a pA2 value of 8.9 in isolated rat vagus nerve studies. This compound effectively inhibits the Bezold-Jarisch reflex in both anesthetized and awake rat models, highlighting its potential applications in neuropharmacological research and studies of gastrointestinal function. Its oral bioavailability makes it a valuable tool for investigating the therapeutic roles of 5-HT3 receptor modulation in various physiological and pathological states.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
