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VNA-932 (WAY-151932)

vasopressin V2-receptor agonist

WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
CHO	EC50	125 nM	Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay	[PMID: 20104850]
CHO	EC50	39.9 nM	Activity at human vasopressin V2 receptor expressed in CHO cells by NFAT-luciferase gene reporter assay	[PMID: 20104850]
CHO	EC50	465 nM	Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay	[PMID: 20104850]
HEK293	EC50	< 1 nM	Agonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as increase in intracellular cAMP level by CRE-luciferase reporter gene assay	[PMID: 19053774]

Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	220460-92-4
Applications	vasopressin V2-receptor agonist
Formula	C₂₃H₁₉ClN₄O
Molecular Weight	402.88
Synonyms	WAY151932; WAY-VNA 932
SMILES	O=C(C1=CC=C(N2N=C(C)C=C2)C=C1Cl)N3CC4=CC=CN4CC5=CC=CC=C53

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.