Fig. 1 · Structure
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WAY-181187 hydrochloride
5-HT6 Agonist
WAY-181187 hydrochloride is a potent and selective full agonist of the 5-HT6 receptor, exhibiting a Ki of 2.2 nM and an EC50 of 6.6 nM. This compound activates 5-HT6 receptor-dependent signaling pathways, including cAMP, Fyn, and ERK1/2 kinase, making it a valuable tool for research into neuropharmacology and the modulation of serotonergic pathways. Its selective action supports investigations into potential therapeutic applications for cognitive disorders and other conditions influenced by serotonin signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 554403-08-6 |
| Applications | 5-HT6 Agonist |
| Formula | C15H14Cl2N4O2S2 |
| Molecular Weight | 417.33 |
| Synonyms | SAX-187 hydrochloride |
| SMILES | NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.