Fig. 1 · Structure
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WB403
TGR5 Activator
WB403 is a potent TGR5 activator with an EC50 of 5.5 μM for human TGR5. It enhances downstream signaling pathways associated with glucose metabolism, notably promoting GLP-1 secretion, improving glucose tolerance, and lowering fasting and postprandial blood glucose levels as well as HbA1c in murine models of type 2 diabetes. Additionally, WB403 contributes to increased pancreatic β-cell mass and the restoration of the islet cell distribution. This compound is valuable for studying mechanisms and therapeutic strategies in type 2 diabetes research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1594041-84-5 |
| Applications | TGR5 Activator |
| Formula | C19H19BrN2OS |
| Molecular Weight | 403.34 |
| SMILES | CCC1=NC=CC(C2=NC(C)=C(S2)COCC3=CC=C(C=C3)Br)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.