Fig. 1 · Structure
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Werner syndrome RecQ helicase-IN-4
WRN Inhibitor
Werner syndrome RecQ helicase-IN-4 is a highly potent inhibitor of the Werner syndrome RecQ helicase (WRN), exhibiting an IC50 value of 0.06 µM. This compound demonstrates significant antiproliferative activity, making it a valuable tool for cancer research and therapeutic development. Its ability to inhibit WRN provides insights into the role of helicase activity in cellular processes and cancer progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2869954-53-8 |
| Applications | WRN Inhibitor |
| Formula | C32H33F3N8O5 |
| Molecular Weight | 666.65 |
| SMILES | O=C(N1CCN(CC1)C2=C(CC)N(CC(NC3=CC=C(C(F)(F)F)C=C3C)=O)C4=NC(C5=CCOCC5)=NN4C2=O)C6=NC=CC=C6O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.