Fig. 1 · Structure
Documents & Downloads
WES-1
CA IX Inhibitor
WES-1 is a selective inhibitor of carbonic anhydrase IX (CA IX) with a Ki value of 55.9 μM. It demonstrates significant anti-proliferative effects across various cancer cell lines, including leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15), and melanoma (LOX IMVI). This compound serves as a valuable tool in cancer research, particularly in studies focused on tumor metabolism and treatment resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2748673-86-9 |
| Applications | CA IX Inhibitor |
| Formula | C20H20N4O3S |
| Molecular Weight | 396.46 |
| SMILES | O=C(NC1=C(S(=O)(N)=O)C=CC=C1)NC2=CC=C(C3=CC=C(C)C=C3)N=C2C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.