Fig. 1 · Structure
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WHI-P180 hydrochloride
RET Inhibitor
WHI-P180 hydrochloride is a potent RET inhibitor that also targets KDR and EGFR. With IC50 values of 5 nM for RET, 66 nM for KDR, and 4 μM for EGFR, it demonstrates significant inhibitory activity across these kinases. This compound is widely utilized in research focused on cancer biology, particularly in studies investigating RET-driven tumors and endothelial growth signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 153437-55-9 |
| Applications | RET Inhibitor |
| Formula | C16H16ClN3O3 |
| Molecular Weight | 333.77 |
| Synonyms | Janex 3 hydrochloride |
| SMILES | COC1=CC2=NC=NC(NC3=CC=CC(O)=C3)=C2C=C1OC.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.