Fig. 1 · Structure
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Withanone
iGluR Inhibitor
Withanone is an iGluR inhibitor derived from the roots of Withania somnifera. It exhibits neuroprotective properties by mitigating cognitive impairment and inhibiting NMDA-induced excitotoxicity in neuron-like cells. Additionally, Withanone impedes the browning of white adipose tissue by disrupting the GRP75-ANT2-UCP1 complex, potentially alleviating cancer-related cachexia. This compound is suitable for research related to tumors and neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 27570-38-3 |
| Applications | iGluR Inhibitor |
| Formula | C28H38O6 |
| Molecular Weight | 470.60 |
| SMILES | C[C@@]12[C@]3([H])[C@]([C@H](O4)[C@H]4[C@]1(CC=CC2=O)O)([H])[C@@]5([H])[C@@](C)([C@]([C@@H]([C@@](O6)([H])CC(C)=C(C)C6=O)C)(O)CC5)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.