Withaphysalin D

Catalog No.: A67331
NMDAR Antagonist
Withaphysalin D is a selective antagonist of the N-methyl-D-aspartate receptor (NMDAR) subtype containing GluN2B. Isolated from water lilies, this compound exhibits neuroprotective properties and has been shown to effectively cross the blood-brain barrier. It is valuable for research applications involving neurobiology and the study of excitatory neurotransmission.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionWithaphysalin D is a selective antagonist of the N-methyl-D-aspartate receptor (NMDAR) subtype containing GluN2B. Isolated from water lilies, this compound exhibits neuroprotective properties and has been shown to effectively cross the blood-brain barrier. It is valuable for research applications involving neurobiology and the study of excitatory neurotransmission.
Product Information
Catalog NumA67331
FormulaC28H34O6
Molecular Weight466.57
CAS Number91599-21-2
SMILESCC(C[C@@H]([C@@]1(OC([C@]23CC[C@@H]4[C@]5(C(CC=CC5=CC[C@H]4[C@@]2(CC[C@@H]31)O)=O)C)=O)C)O6)=C(C)C6=O
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