Fig. 1 · Structure
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WIZ degrader 2
WIZ Degrader
WIZ Degrader 2 is an efficient degrader targeting widely interspaced zinc finger motifs, with an AC50 of 0.011 μM. This compound enhances the expression of fetal hemoglobin (HbF) with an EC50 of 0.038 μM. WIZ Degrader 2 is a valuable tool for research into inherited blood disorders, facilitating studies aimed at understanding and potentially treating these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2839552-69-9 |
| Applications | WIZ Degrader |
| Formula | C24H33N5O3 |
| Molecular Weight | 439.55 |
| SMILES | O=C(NC(CC1)=O)N1C(C=NN2C=C3)=C2C=C3C[C@H]4C[C@@H](N(CC4)CC5CCOCC5)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.