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WIZ degrader 3

WIZ Degrader

WIZ Degrader 3 (Compound 29) is a selective degrader targeting widely interspaced zinc finger motifs (WIZ), exhibiting an AC50 of 6.4 nM. This compound effectively induces the expression of fetal hemoglobin (HbF) with an EC50 of 45 nM. WIZ Degrader 3 is valuable for research in blood disorders, including sickle cell disease and β-thalassemia, facilitating studies on therapeutic strategies for these conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2839637-72-6
Applications	WIZ Degrader
Formula	C₁₈H₂₃N₅O₃
Molecular Weight	357.41
SMILES	O=C(NC(CC1)=O)N1C2=NOC3=CC=C(C=C23)CN4C[C@@H](N(CC4)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.