Fig. 1 · Structure
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WIZ degrader 4
WIZ Degrader
WIZ Degrader 4 is a WIZ degrader that exhibits an AC50 value of 160 nM. This compound plays a critical role in targeted protein degradation, facilitating the investigation of underlying mechanisms in sickle cell disease (SCD) and thalassemia. Its application in research aids in understanding disease pathology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2879250-22-1 |
| Applications | WIZ Degrader |
| Formula | C20H25N3O4 |
| Molecular Weight | 371.43 |
| SMILES | CCN1CCC[C@H](C1)OC2=CC=C3C(N(CC3=C2)C4CCC(NC4=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.