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WIZ degrader 6

WIZ Degrader

WIZ Degrader 6 is a potent WIZ degrader with an EC50 of less than 0.01 μM, effectively targeting the WIZ protein. This compound plays a critical role in cellular pathways associated with sickle cell disease, providing a valuable tool for investigating disease mechanisms and potential therapeutic approaches. Its high specificity and efficacy make it suitable for research applications focused on cellular degradation processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3036553-87-1
Applications	WIZ Degrader
Formula	C₂₈H₂₂FN₅O₅
Molecular Weight	527.50
SMILES	O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NC4=C(C=NN5C)C5=CC=C4OC6=C(C)C=CC=C6F)=CC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.