WK500B is a potent BCL6 inhibitor that disrupts BCL6-corepressor interactions, leading to the reactivation of BCL6 target genes. With a dissociation constant (KD) of 1.61 μM, it demonstrates significant cytotoxicity against diffuse large B-cell lymphoma (DLBCL) cells, inducing apoptosis and cell cycle arrest. Additionally, WK500B effectively suppresses germinal center formation in C57BL/6 mice and reduces DLBCL tumor growth in SCID xenograft models without noticeable toxicity. This compound is valuable for research in the pathogenesis of DLBCL and potential therapeutic interventions.
WK500B is a potent BCL6 inhibitor that disrupts BCL6-corepressor interactions, leading to the reactivation of BCL6 target genes. With a dissociation constant (KD) of 1.61 μM, it demonstrates significant cytotoxicity against diffuse large B-cell lymphoma (DLBCL) cells, inducing apoptosis and cell cycle arrest. Additionally, WK500B effectively suppresses germinal center formation in C57BL/6 mice and reduces DLBCL tumor growth in SCID xenograft models without noticeable toxicity. This compound is valuable for research in the pathogenesis of DLBCL and potential therapeutic interventions.
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