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WRN-IN-19

WRN Helicase Inhibitor

WRN-IN-19 is a covalent inhibitor of the WRN helicase, demonstrating a pIC50 of 5.4 at 0 hours and 7.5 at 4 hours in DNA unwinding assays. This compound exhibits synthetic lethality in high microsatellite instability (MSI-H) cancer cells, making it a valuable tool for studying the mechanisms of DNA repair and potential therapeutic strategies in cancer research. Its targeted action on WRN helicase positions it as a critical reagent for investigations into the role of helicases in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3058652-58-4
Applications	WRN Helicase Inhibitor
Formula	C₂₃H₂₆F₃N₃O₃
Molecular Weight	449.47
SMILES	O=C(N1C[C@@H](C(N2CC3(CCC3)C2)=O)N(C(C=C)=O)CC1)CC4=CC=C(C(F)(F)F)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.