Documents & Downloads

WRN-IN-20

WRN Degrader

WRN-IN-20 is a targeted WRN degrader known for its effective degradation of the Werner syndrome protein (WRN). This compound demonstrates significant degradation activity in various cell lines, including HCT-116 (DC50 = 1.7 µM), SW-48 (DC50 = 3.0 µM), and SW-480 (DC50 = 5.9 µM). WRN-IN-20 exhibits potent anti-proliferative, pro-apoptotic, migration-inhibiting, and DNA damage-inducing effects, particularly in MSI-H cancer cells. This reagent is suitable for research applications focused on cancer biology and therapeutic strategies involving WRN modulation.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3095277-20-3
Applications	WRN Degrader
Formula	C₃₇H₄₄F₃N₅O₅S
Molecular Weight	727.84
SMILES	O=C(NCCCCCOC1=CC=C(C2=NC(S(=O)(NCC(NC3=CC=C(C)C=C3)=O)=O)=NC(C(F)(F)F)=C2)C=C1)CC45C[C@H](C6)C[C@@H](C5)C[C@H]6C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.