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WRN-IN-23

WRN Inhibitor

WRN-IN-23 is a selective inhibitor of the Werner Syndrome helicase (WRN), targeting its ATP-dependent helicase domain activity. This compound effectively interferes with DNA unwinding processes, making it a valuable tool for investigating cancers associated with microsatellite instability (MSI) and defective DNA mismatch repair (dMMR) mechanisms. WRN-IN-23's ability to modulate WRN activity provides insights into the roles of helicases in cancer biology and may contribute to the development of therapeutic strategies for these tumor types.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2923008-65-3
Applications	WRN Inhibitor
Formula	C₁₆H₂₀N₂O₄S
Molecular Weight	336.41
SMILES	O=C1NC(C2CCCCC2)=CC=C1C(N[C@H]3C=CS(=O)(C3)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.