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WRN inhibitor 11

WRN Inhibitor

WRN Inhibitor 11 is a potent orally active inhibitor of the WRN helicase, exhibiting an IC50 value of 63 nM. This compound disrupts the helicase activity of WRN, a critical enzyme involved in DNA repair and maintenance of genomic stability. WRN Inhibitor 11 is valuable for research applications in cancer biology and studies involving disorders linked to defective DNA repair mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3058317-61-3
Applications	WRN Inhibitor
Formula	C₃₄H₃₅ClF₃N₉O₅
Molecular Weight	742.15
SMILES	CCC1=C(C(N2N=C(N=C2N1CC(NC3=CC(Cl)=C(C=C3C)C(F)(F)F)=O)C4=CCOCC4)=O)N5C6CN(C(C7=NC=NC(C)=C7O)=O)CC5CC6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.