Fig. 1 · Structure
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WRN inhibitor 4
WRN Inhibitor
WRN Inhibitor 4 is a selective inhibitor of the Werner Syndrome ATP-dependent helicase (WRN), demonstrating a pIC50 of ≥ 7. This compound effectively modulates WRN activity, making it a valuable tool for studying tumors characterized by a high mutation burden. Its application in cancer research aids in elucidating the role of WRN in genomic stability and tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2923009-45-2 |
| Applications | WRN Inhibitor |
| Formula | C16H14N2O5S |
| Molecular Weight | 346.36 |
| SMILES | OC1=C(C2=CC=CC=C2)NC(C(C(N[C@@H]3C=CS(=O)(C3)=O)=O)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.