Fig. 1 · Structure
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WRN inhibitor 5
WRN Inhibitor
WRN Inhibitor 5 is a cyclic vinyl sulfone compound that selectively inhibits the Werner Syndrome ATP-dependent helicase (WRN). This inhibitor is crucial for studying cancer, particularly in contexts involving microsatellite instability (MSI) and defective DNA mismatch repair (dMMR) mechanisms. Its ability to target WRN provides valuable insights into the molecular underpinnings of certain cancer types and aids in the development of therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2923009-95-2 |
| Applications | WRN Inhibitor |
| Formula | C23H20N2O6S |
| Molecular Weight | 452.48 |
| SMILES | OC(C=C(C(N1)=O)C(N[C@@H]2C=CS(=O)(C2)=O)=O)=C1C(C=CC=C3)=C3OCC4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.