Fig. 1 · Structure
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WS-691
ABCB1 Modulator
WS-691 is a selective modulator of the ATP-binding cassette sub-family B member 1 (ABCB1). This compound directly binds to ABCB1, stabilizing its structure, which inhibits its efflux function and activates its ATPase activity. By elevating intracellular levels of Paclitaxel, WS-691 reduces the necessary dosage of this chemotherapeutic agent in cancer cells that overexpress ABCB1. It enhances the sensitivity of colon cancer cells to Paclitaxel, making it a valuable tool for studying drug resistance mechanisms and improving cancer treatment strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2035417-32-2 |
| Applications | ABCB1 Modulator |
| Formula | C20H16FN7S |
| Molecular Weight | 405.45 |
| SMILES | FC1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=C(N4)C=CC=C5)=NN32)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.