Fig. 1 · Structure
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WSF1-IN-1
WSF1 Inhibitor
WSF1-IN-1 is an orally active inhibitor targeting WSF1, which is implicated in Wolfram syndrome-related tumors. With an IC50 of 0.33 μM in HepG2 parental cell lines and over 27 μM in HepG2 WFS1 knockout models, WSF1-IN-1 demonstrates significant biological activity that can facilitate research into tumor biology associated with WSF1 dysfunction. This compound is suitable for studies aimed at understanding the therapeutic potential against WSF1-related malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2379577-82-7 |
| Applications | WSF1 Inhibitor |
| Formula | C20H21F3N8O |
| Molecular Weight | 446.43 |
| SMILES | CN([C@H]1C)C2=NC(NCC(C=N3)=CN3CC(C=C4)=CN=C4C(F)(F)F)=NC(C)=C2NC1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.