Fig. 1 · Structure
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WX8
PIKFYVE Inhibitor
WX8 is an ATP-competitive inhibitor of PIKFYVE, exhibiting Kd values of 0.9 nM for PIKFYVE and 340 nM for PIP4K2C. This compound specifically inhibits lysosomal fission while leaving homotypic lysosomal fusion unaffected. WX8 is utilized in research focused on autophagy-dependent cancer pathways, providing insights into lysosomal dynamics and their role in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 232935-92-1 |
| Applications | PIKFYVE Inhibitor |
| Formula | C22H22N8O |
| Molecular Weight | 414.46 |
| Synonyms | Ro 91-4714 |
| SMILES | C1(/C=N/NC2=NC(NC3=CC=CC=C3)=NC(N4CCOCC4)=N2)=CNC5=C1C=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.