X-370

Name: X-370
Brand: Adooq Bioscience
SKU: A25681
Rating: 5 (288 reviews)

Catalog No.: A25681

PI3Kδ Inhibitor

X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL).

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Biological Activity

Description	X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL).

Product Information

Catalog Num	A25681
Formula	C27H31F2N9O2
Molecular Weight	551.59
CAS Number	1280725-80-5
SMILES	FC(F)C1=NC2=C(N1C3=NC(N4CCOCC4)=NC5=C3N=CN5C6CCN(C(N7CCCC7)=O)CC6)C=CC=C2

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