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XAN-5

MtG4 Ligand

XAN-5 is a selective mitochondrial DNA G-quadruplex (mtG4) ligand with a dissociation constant (Kd) of 3.8 μM that binds to and stabilizes mtG4 structures. This compound disrupts mitochondrial gene transcription and DNA replication, leading to mitochondrial dysfunction, increased reactive oxygen species (ROS) production, cell cycle arrest in the G0 phase, and caspase-dependent apoptosis. Additionally, XAN-5 inhibits autophagy and promotes immunogenic cell death while significantly reducing tumor growth in a murine model of liver cancer, enhancing infiltration of CD4+ and CD8+ T cells. XAN-5 serves as a valuable tool for investigating therapeutic strategies in liver cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3062796-70-4
Applications	MtG4 Ligand
Formula	C₂₉H₂₈ClNO₇S
Molecular Weight	570.05
SMILES	CCN(C1=CC2=[O+]C3=C(CCC/C3=C\C4=CC=CS4)C(C5=CC=CC=C5C(O)=O)=C2C=C1)CC.O=Cl(=O)([O-])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.