Fig. 1 · Structure
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XAP044
mGlu7 Antagonist
XAP044 is a highly selective antagonist of the metabotropic glutamate receptor subtype 7 (mGlu7), which serves as a key presynaptic modulator of neurotransmission in the central nervous system. It is characterized by significant brain permeability and has been shown to exhibit a broad range of anti-stress effects, as well as antidepressant and anxiolytic-like activity in rodent behavioral models. This compound is useful for research applications aimed at understanding mGlu7's role in neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 196928-50-4 |
| Applications | mGlu7 Antagonist |
| Formula | C15H9IO4 |
| Molecular Weight | 380.13 |
| SMILES | O=C1C2=CC=C(O)C=C2OC=C1OC3=CC=C(I)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.