Xentry is a cell-penetrating peptide (CPP) derived from the hepatitis B virus, featuring a sequence of seven amino acids (LCLRPVG). This peptide facilitates the efficient delivery of large biomolecules, such as antibodies, siRNAs, and enzymes, to various tissues in vivo, excluding circulating blood cells. Studies demonstrate that Xentry conjugated with anti-B-raf antibodies or siRNAs effectively induces cell death in B-raf-dependent melanoma cells, highlighting its potential in targeted cancer research and therapeutic applications.
Xentry is a cell-penetrating peptide (CPP) derived from the hepatitis B virus, featuring a sequence of seven amino acids (LCLRPVG). This peptide facilitates the efficient delivery of large biomolecules, such as antibodies, siRNAs, and enzymes, to various tissues in vivo, excluding circulating blood cells. Studies demonstrate that Xentry conjugated with anti-B-raf antibodies or siRNAs effectively induces cell death in B-raf-dependent melanoma cells, highlighting its potential in targeted cancer research and therapeutic applications.
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