Fig. 1 · Structure
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XIAP/cIAP1 antagonist-1
XIAP/cIAP1 Antagonist
XIAP/cIAP1 antagonist-1 is a potent and orally bioavailable antagonist of the X-linked inhibitor of apoptosis protein (XIAP) and cellular inhibitor of apoptosis protein 1 (cIAP1), exhibiting EC50 values of 5.1 nM and 0.32 nM, respectively. This compound effectively inhibits tumor growth in a dose-dependent manner in vivo, making it a valuable tool for research into apoptosis regulation and cancer therapeutics. Its selective action on XIAP and cIAP1 positions it as a significant candidate for studies focused on targeting apoptosis pathways in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1403898-55-4 |
| Applications | XIAP/cIAP1 Antagonist |
| Formula | C29H40FN5O2 |
| Molecular Weight | 509.66 |
| SMILES | C[C@H]1N(C[C@@H]2N(CC(N3CC(C)(C)C4=NC=C(CC5=CC=C(F)C=C5)C=C43)=O)C[C@@H](C)NC2)CCOC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.