Fig. 1 · Structure
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XL413 monohydrochloride
Cdc7 Inhibitor
XL413 monohydrochloride is a potent and selective inhibitor of the Cdc7 kinase, operating through an ATP-competitive mechanism with an IC50 of 3.4 nM. In addition to its primary activity, XL413 exhibits significant inhibitory effects on CK2 and PIM1, with respective IC50 values of 215 nM and 42 nM, as well as an EC50 of 118 nM on pMCM. This compound is valuable for exploring cell cycle regulation and kinase signaling pathways in various research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2062200-97-7 |
| Applications | Cdc7 Inhibitor |
| Formula | C14H13Cl2N3O2 |
| Molecular Weight | 326.18 |
| Synonyms | BMS-863233 monohydrochloride |
| SMILES | O=C1C(OC2=CC=C(Cl)C=C23)=C3N=C([C@H]4NCCC4)N1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.