XMU-MP-9 is a bifunctional small molecule that simultaneously targets the C2 domain of Nedd4-1 and an allosteric site on K-Ras. By bridging these two proteins, XMU-MP-9 enhances the Nedd4-1–K-Ras interaction and induces conformational changes within the complex, leading to ubiquitination and subsequent degradation of multiple mutant K-Ras isoforms. This mechanism results in the suppression of proliferation in cancer cells harboring K-Ras mutations. XMU-MP-9 is a valuable research tool for investigating the therapeutic targeting of K-Ras–driven malignancies, including colon, lung, and pancreatic cancers.
XMU-MP-9 is a bifunctional small molecule that simultaneously targets the C2 domain of Nedd4-1 and an allosteric site on K-Ras. By bridging these two proteins, XMU-MP-9 enhances the Nedd4-1–K-Ras interaction and induces conformational changes within the complex, leading to ubiquitination and subsequent degradation of multiple mutant K-Ras isoforms. This mechanism results in the suppression of proliferation in cancer cells harboring K-Ras mutations. XMU-MP-9 is a valuable research tool for investigating the therapeutic targeting of K-Ras–driven malignancies, including colon, lung, and pancreatic cancers.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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