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XPO1-ligand-1

XPO1 Ligand

XPO1-ligand-1 is a selective ligand for XPO1, a key nuclear export protein. It plays a critical role in the development of PROTAC molecules, specifically serving as a building block for synthesizing PROTAC XPO1 degrader-1. This compound is valuable for research in targeted protein degradation and therapeutic applications related to cancer and other diseases associated with XPO1 dysregulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1076236-11-7
Applications	XPO1 Ligand
Formula	C₁₄H₁₁ClF₃N₃O₄
Molecular Weight	377.70
SMILES	ClC1=C(C(F)(F)F)C=CC(NN2C(C(C)=C(CCC(O)=O)C2=O)=O)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.