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XS018661

ENL/AF9 Inhibitor

XS018661 is a dual inhibitor targeting the YEATS domains of ENL and its paralog AF9, exhibiting IC50 values of 1.6 μM and 3 μM, respectively. This compound demonstrates binding affinities with Kd values of 754 nM and 523 nM for ENL and AF9. XS018661 is useful in studying the roles of these protein interactions in transcriptional regulation and epigenetic processes, making it a valuable tool for research in cancer biology and chromatin dynamics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	878415-59-9
Applications	ENL/AF9 Inhibitor
Formula	C₂₂H₂₄N₄O₃
Molecular Weight	392.46
SMILES	O=C(OC)C1=CC=C(C=C1)C(=O)NC=2C=CC=3N=C(NC3C2)CN4CCCCC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.