Fig. 1 · Structure
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XVA143
LFA-1 Inhibitor
XVA143 is an allosteric antagonist targeting the leukocyte function-associated antigen-1 (LFA-1). This compound inhibits LFA-1 dependent firm adhesion while promoting adhesion under shear flow and rolling conditions in both in vitro and in vivo models. XVA143 is primarily used in studies related to immunology and inflammation, facilitating research on leukocyte adhesion dynamics and related therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 264275-77-6 |
| Applications | LFA-1 Inhibitor |
| Formula | C25H21Cl2N3O8 |
| Molecular Weight | 562.36 |
| SMILES | O=C(O)[C@H](CNC(C1=CC(O)=CC(O)=C1)=O)NC(C2=C(Cl)C=C(C(NCC3=CC=CC(O)=C3)=O)C=C2Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.