Fig. 1 · Structure
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Xylobiose
CLDN2 Inhibitor
Xylobiose is an orally active inhibitor of Claudin 2 (CLDN2) that regulates intestinal barrier function and metabolic signaling pathways. It inhibits CLDN2 expression to decrease intestinal permeability, while also inducing HSP27 to enhance cellular protection. Additionally, Xylobiose modulates the miR-122a/miR-33a axis to inhibit hepatic lipid synthesis and improve insulin sensitivity. This compound is applicable in research surrounding type 2 diabetes and metabolic syndrome, as it strengthens intestinal barrier integrity and mitigates oxidative stress and inflammation while lowering blood glucose and lipid levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 6860-47-5 |
| Applications | CLDN2 Inhibitor |
| Formula | C10H18O9 |
| Molecular Weight | 282.24 |
| Synonyms | 1,4-β-D-Xylobiose; 1,4-D-Xylobiose |
| SMILES | O=C[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1[C@@H]([C@H]([C@H](O)CO1)O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.