Fig. 1 · Structure
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XZA-1
HADH Activator
XZA-1 is an activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH). It enhances the intracellular levels of acetoacetyl-CoA, leading to acetoacetylation of Chromobox Protein Homolog 4 (CBX4) at lysine 106 (K106). XZA-1 demonstrates antitumor activity in xenograft models of human hepatocellular carcinoma, specifically in SMMC7721 cells overexpressing CBX4. This compound is valuable for research into the mechanisms underlying hepatocellular carcinoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1282141-20-1 |
| Applications | HADH Activator |
| Formula | C15H16N2O2 |
| Molecular Weight | 256.30 |
| SMILES | O=C(C1=NOC2=C1CCCCC2)NC3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.