Yamogenin, a diastereomer of diosgenin, acts as an antagonist of the liver X receptor (LXR). It has been shown to inhibit triacylglyceride (TG) accumulation in HepG2 hepatocytes by downregulating fatty acid synthesis gene expression. This steroidal saponin exhibits in vitro cytotoxic, antioxidant, and antimicrobial properties, inducing cell death through both extrinsic and intrinsic apoptosis pathways. Yamogenin has potential applications in research focused on gastric cancer.
Yamogenin, a diastereomer of diosgenin, acts as an antagonist of the liver X receptor (LXR). It has been shown to inhibit triacylglyceride (TG) accumulation in HepG2 hepatocytes by downregulating fatty acid synthesis gene expression. This steroidal saponin exhibits in vitro cytotoxic, antioxidant, and antimicrobial properties, inducing cell death through both extrinsic and intrinsic apoptosis pathways. Yamogenin has potential applications in research focused on gastric cancer.
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