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YF135

KRAS(G12C) Degrader

YF135 is a reversible-covalent PROTAC specifically targeting KRAS(G12C). This compound facilitates the degradation of KRAS(G12C) by linking a potent KRAS G12C inhibitor with a VHL ligand scaffold, effectively promoting the proteasomal pathway via E3 ligase VHL. YF135 significantly reduces phospho-ERK levels, making it a valuable tool for research applications focused on KRAS(G12C)-associated pathways in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2913177-53-2
Applications	KRAS(G12C) Degrader
Formula	C₆₃H₇₅ClN₁₂O₇S
Molecular Weight	1179.86
SMILES	CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCOCCCN4CCC[C@H]4COC5=NC6=C(C(N7CCN([C@H](C7)CC#N)C(/C(C#N)=C/C8CC8)=O)=N5)CCN(C6)C9=CC=CC%10=C9C(Cl)=CC=C%10)=O)=O)O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.