Fig. 1 · Structure
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YH16899
KRS-67LR Inhibitor
YH16899 is a potent inhibitor of Lysyl-tRNA synthetase (KRS), obstructing its membrane translocation and disrupting its interaction with the 67LR protein. This compound has demonstrated significant efficacy in inhibiting tumor metastasis in various mouse models, making it a valuable tool for cancer research. YH16899 can be utilized to study the role of KRS in cancer progression and explore novel therapeutic approaches targeting metastasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1428623-14-6 |
| Applications | KRS-67LR Inhibitor |
| Formula | C19H13F5N2O3S |
| Molecular Weight | 444.38 |
| SMILES | O=C(C1=CC=CC(C(F)(F)F)=C1)/N=C2N(C(CC)C(O)=O)C3=CC(F)=C(F)C=C3S/2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.