YM-202074 fumarate is a selective allosteric antagonist of the metabotropic glutamate receptor type 1 (mGluR1), demonstrating high affinity with a Ki of 4.8 nM. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, exhibiting an IC50 of 8.6 nM. Additionally, YM-202074 fumarate exhibits potent neuroprotective effects in models of transient middle cerebral artery occlusion, making it a valuable tool for research on neuroprotection and mGluR1-related pathways.
YM-202074 fumarate is a selective allosteric antagonist of the metabotropic glutamate receptor type 1 (mGluR1), demonstrating high affinity with a Ki of 4.8 nM. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, exhibiting an IC50 of 8.6 nM. Additionally, YM-202074 fumarate exhibits potent neuroprotective effects in models of transient middle cerebral artery occlusion, making it a valuable tool for research on neuroprotection and mGluR1-related pathways.
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