Fig. 1 · Structure
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YM-202074 fumarate
mGluR1 Antagonist
YM-202074 fumarate is a selective allosteric antagonist of the metabotropic glutamate receptor type 1 (mGluR1), demonstrating high affinity with a Ki of 4.8 nM. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, exhibiting an IC50 of 8.6 nM. Additionally, YM-202074 fumarate exhibits potent neuroprotective effects in models of transient middle cerebral artery occlusion, making it a valuable tool for research on neuroprotection and mGluR1-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 299900-84-8 |
| Applications | mGluR1 Antagonist |
| Formula | C56H72N8O16S2 |
| Molecular Weight | 1177.34 |
| SMILES | OC(/C=C/C(O)=O)=O.CN(C1CCCCC1)C(C2=CN3C4=CC(CN(C)CCOC)=CC=C4N=C3S2)=O.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O.CN(C5CCCCC5)C(C6=CN7C8=CC(CN(C)CCOC)=CC=C8N=C7S6)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.